Inadequate/Extensive Metabolizers, CYP2D6 The development from the active metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Roughly seven% from the populace has lessened activity with the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme method. These people today are “weak metabolizers” of debrisoquine, dextromethorphan and tr

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